An estimated
1.3–4.0
million cases
of cholera
occur worldwide each year.4
Enjoying the local fare when you travel is one of the best ways to immerse yourself in a culture. However, when it comes to food and drink, you should understand the risk that cholera can present.3
Cholera is an intestinal infection caused by the bacteria Vibrio cholerae serogroup O1 or O139.3 You can get cholera by eating food or drinking water that has been contaminated with fecal matter from people who have been infected with the bacteria.3 Cholera is most commonly seen as acute watery diarrhea in an afebrile person. The infection is often mild or without symptoms, but it can be severe in about 10% of cholera cases. People who get severe cholera can experience symptoms such as excessive watery diarrhea, vomiting, and muscle cramps. Untreated cholera can cause rapid loss of body fluids, which can lead to dehydration, shock, and death within hours.3
Since the prevention steps (food, water, and personal hygiene precautions) that CDC recommends you take cannot give you total protection when traveling in areas of active cholera transmission, it's smart to do all you can to help protect yourself.3
It is estimated that cholera is regularly found in about 50 countries, primarily in South and Southeast Asia and Africa.3
VAXCHORA can help protect you from cholera when you travel to areas of active cholera transmission.3
VAXCHORA is a prescription vaccine to help protect against cholera caused by Vibrio cholerae serogroup O1. You should only take VAXCHORA if you are between 2 and 64 years old and plan to travel to places where there is cholera.2
VAXCHORA has not been shown to work in people who live in places where there is cholera and people who have pre-existing protection from cholera or have had a cholera vaccine. VAXCHORA has not been shown to protect against cholera caused by bacteria not covered by the vaccine.2 See “Important Safety Information for VAXCHORA” below for more details.
Ask your healthcare provider or pharmacist about VAXCHORA
before your
next trip.
VAXCHORA is a single-dose oral vaccine.2
How to take VAXCHORA2:
Do not take VAXCHORA if you are allergic to any ingredient of VAXCHORA or have had an allergic reaction to any cholera vaccine.2
In a clinical trial of adults aged 18 to 45 who were deliberately exposed to live cholera after being vaccinated, VAXCHORA was2:
effective at 10 days post-vaccination compared with placebo in preventing moderate to severe diarrhea.
effective at 3 months post-vaccination compared with placebo in preventing moderate to severe diarrhea.
Most common adverse events reported after VAXCHORA administration in clinical trials with adults aged 18 to 64 years include tiredness (31%), headache (29%), abdominal pain (19%), nausea/vomiting (18%), lack of appetite (17%), and diarrhea (4%).2
Ask how VAXCHORA may help protect you
while traveling to cholera-affected areas.
VAXCHORA is a prescription vaccine used in children at least 2 years old and adults up to 64 years old for a disease called cholera. If you are traveling to areas affected by cholera, you can take VAXCHORA by mouth to help protect you against the type of cholera caused by the bacteria Vibrio cholerae serogroup O1.
VAXCHORA has not been shown to work for:
Do not use VAXCHORA if you have had a serious allergic reaction to any ingredient of VAXCHORA or to a previous dose of any cholera vaccine.
VAXCHORA was not studied in people with a weakened immune system. The vaccine may not protect these people.
It is important to tell your healthcare provider (HCP) if:
In clinical trials of adults (18–45 years old), the most common side effects were tiredness, headache, stomach pain, nausea, vomiting, loss of appetite, and diarrhea. In children and adolescents (2–17 years old), the most common side effects were headache, tiredness, stomach pain, loss of appetite, and nausea.
These are not all the possible side effects of VAXCHORA. Patients should always ask their healthcare professionals for medical advice about the appropriate use of vaccines and adverse events. To report SUSPECTED ADVERSE REACTIONS, contact Bavarian Nordic at 1-844-4BAVARIAN or the US Department of Health and Human Services by either visiting www.vaers.hhs.gov/reportevent.html or calling 1-800-822-7967.
Tell your HCP about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Certain treatments, like antibiotics, some anti-malaria medications, and therapies that can weaken the immune system, can interfere with how VAXCHORA works. As needed, your doctor can discuss with you whether to postpone or decide against taking VAXCHORA.
Vaccination with VAXCHORA does not eliminate the need for you to be careful about the food and water you consume in cholera-affected areas. Food and water that have been contaminated with fecal matter from people who are infected with cholera bacteria is the biggest source of risk for a traveler.
This summary provides basic information about VAXCHORA but it does not include all information known about this vaccine. Talk to your HCP or pharmacist about this information. Your HCP is the best person to help you decide if VAXCHORA is right for you.
For more information about VAXCHORA, please see full Prescribing Information.
FDA, U.S. Food and Drug Administration.
© 2024 Bavarian Nordic Inc. All rights reserved. VAXCHORA® and the VAXCHORA® logo are registered trademarks of Bavarian Nordic A/S.
US-VAX-2300011 | March 2024
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